GNG7 G protein subunit gamma 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GNG7provided by HGNC
Official Full Name: G protein subunit gamma 7provided by HGNC
Primary source: HGNC:HGNC:4410
See related: Ensembl:ENSG00000176533 MIM:604430; AllianceGenome:HGNC:4410
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HG3B
Summary: Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within behavioral fear response; locomotory behavior; and receptor guanylyl cyclase signaling pathway. Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in brain (RPKM 18.8), heart (RPKM 10.5) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (2511219..2702694, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (2487421..2678899, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (2511217..2702692, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of GNG7 as a novel biomarker and potential therapeutic target for gastric cancer via bioinformatic analysis and in vitro experiments.
Title: Identification of GNG7 as a novel biomarker and potential therapeutic target for gastric cancer via bioinformatic analysis and in vitro experiments.
Long non-coding RNA LINC00472 inhibits oral squamous cell carcinoma via miR-4311/GNG7 axis.
Title: Long non-coding RNA LINC00472 inhibits oral squamous cell carcinoma via miR-4311/GNG7 axis.
MicroRNA miR-19b-3p mediated G protein gamma subunit 7 (GNG7) loss contributes lung adenocarcinoma progression through activating Hedgehog signaling.
Title: MicroRNA miR-19b-3p mediated G protein γ subunit 7 (GNG7) loss contributes lung adenocarcinoma progression through activating Hedgehog signaling.
GNG7 and ADCY1 as diagnostic and prognostic biomarkers for pancreatic adenocarcinoma through bioinformatic-based analyses.
Title: GNG7 and ADCY1 as diagnostic and prognostic biomarkers for pancreatic adenocarcinoma through bioinformatic-based analyses.
G protein gamma 7 suppresses progression of lung adenocarcinoma by inhibiting E2F transcription factor 1.
Title: G protein gamma 7 suppresses progression of lung adenocarcinoma by inhibiting E2F transcription factor 1.
Elevated MicroRNA 183 Impairs Trophoblast Migration and Invasiveness by Downregulating FOXP1 Expression and Elevating GNG7 Expression during Preeclampsia.
Title: Elevated MicroRNA 183 Impairs Trophoblast Migration and Invasiveness by Downregulating FOXP1 Expression and Elevating GNG7 Expression during Preeclampsia.
GNG7 is a tumor suppressor gene in Clear cell renal cell carcinoma progression.
Title: G Protein γ subunit 7 loss contributes to progression of clear cell renal cell carcinoma.
GNG7 is a highly specific promoter methylated gene associated with head and neck cancer.
Title: Identification of guanine nucleotide-binding protein γ-7 as an epigenetically silenced gene in head and neck cancer by gene expression profiling.
Loss of GNG7 protein expression is a frequent event in head and neck cancer with hypermethylation of the promoter region of GNG7 being probably the mechanism for the observed inactivation.
Title: Loss of protein expression and recurrent DNA hypermethylation of the GNG7 gene in squamous cell carcinoma of the head and neck.
Reduced expression of G-gamma 7 is associated with the histological grade of EHCC and may prove to be a useful marker for predicting the prognosis of human EHCC.
Title: Human G-protein gamma 7 in extrahepatic cholangiocarcinoma and its clinicopathological significance.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S3035 (e-PCR)
- UniSTS:1579

D8S2279 (e-PCR)
- UniSTS:473907

D19S565 (e-PCR), detects polymorphism
- UniSTS:57934

D1S1423 (e-PCR)
- UniSTS:149619

D11S3114 (e-PCR)
- UniSTS:152207

SHGC-153161 (e-PCR)
- UniSTS:182423

D22S296 (e-PCR)
- UniSTS:147641

GDB:631802 (e-PCR)
- UniSTS:158429

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G-protein beta-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in behavioral fear response	IEA Inferred from Electronic Annotation more info
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in receptor guanylyl cyclase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in regulation of adenylate cyclase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Names: guanine nucleotide binding protein (G protein), gamma 7; heterotrimeric guanine nucleotide-binding protein 3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_052847.3 → NP_443079.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

See identical proteins and their annotated locations for NP_443079.1

Status: VALIDATED

Source sequence(s)

AC005512, BC014466, BC053630, DA247608

Consensus CDS

CCDS12091.1

UniProtKB/Swiss-Prot

B2R496, O60262

Related

ENSP00000371594.2, ENST00000382159.8

Conserved Domains (1) summary

smart00224
Location:7 → 68

GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

2511219..2702694 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047438629.1 → XP_047294585.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

UniProtKB/Swiss-Prot

B2R496, O60262

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

2487421..2678899 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054320580.1 → XP_054176555.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

UniProtKB/Swiss-Prot

B2R496, O60262
XM_054320581.1 → XP_054176556.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

UniProtKB/Swiss-Prot

B2R496, O60262